Immune Repertoire

Advances in Immune Repertoire Measurement and Analysis

New Developments in the Study of the Adaptive Immune Response

The application of high-throughput sequencing of immune receptors has opened a new window to understand the dynamics of the adaptive immune system. CZ Biohub brings together 24 speakers from across the globe to share their leading research on how they are generating and using these data in new and innovative ways.

The conference offers presentations and poster sessions on six different topics:

  • Applications
  • B cells
  • Genetics
  • Models/Computation
  • T cells
  • Technology

Program Schedule

Wednesday, January 23, 2019




8:55 a.m. – Welcome to Immune Repertoire


9 a.m. – Ligand hunting for orphan receptors
9:25 a.m. – Decoding T and NK cell recognition
9:50 a.m. – Lymphocyte diversity: matching specificity and function
  • Federica Sallusto, Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona/Institute of Microbiology, ETH Zurich
10:15 a.m. – TCR cross-reactivity and specificity in responses against tumors and pathogens
  • Paul Thomas, St. Jude Children’s Research Hospital



11 a.m. – Clonal dynamics versus hypermutation in antibody affinity maturation
11:25 a.m. – Analysis of B cell antibody repertoires from next-generation sequencing (in autoimmunity and other diseases)
11:50 a.m. – Identifying responding clonotypes in immune repertoires
12:15 p.m. – Deep generative models for T cell receptor protein sequences



1:45 p.m. – Allelic and structural diversity in the human immunoglobulin loci
2:10 p.m. – RNA editing and the generation of heterogeneity in immune cell populations
3 p.m. – Immunogenomics one cell at a time
3:25 p.m. – Characterizing population-level haplotype diversity in the human immunoglobulin loci and the role of germline variation in the antibody repertoire

Thursday, January 24, 2019


9 a.m. – Tools for T cells: Specificity and function in autoimmunity, infectious diseases and cancer



9:25 a.m. – The human serological Antibody repertoire in health and disease
9:50 a.m. – Multi-dimensional T cell repertoire profiling
10:15 a.m. – The potential of full length cDNA sequencing to investigate immune repertoires



11 a.m. – Commonality despite exceptional diversity in the baseline human antibody repertoire
11:25 a.m. – An evolutionary arms race: HIV-1 vs broadly neutralizing antibodies
11:50 a.m. – Epitope focusing to create new vaccines
  • Peter KimStanford University/Chan Zuckerberg Biohub

B Cells


12:15 p.m. – Antibody evolution in the presence or absence of clonal selection
  • Antonio Lanzavecchia, Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland and Vir Biotechnology, Inc.
1:45 p.m. – BRepertoire and our insights into immune aging
2:10 p.m. – Origins of antibody diversity
3 p.m. – Evolution of the human memory B cell response to a parasite antigen
3:25 p.m. – Influenza immunity in context
3:50 p.m. – Closing remarks

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