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Seeking Applications for a
New CZ Biohub

We’re accepting joint applications from universities and other research institutions to create the next Biohub in the network.

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MANUEL LEONETTI, PH.D.

Group Leader, Quantitative Cell Science

How is the human cell built? While the human genome sequence provides us with the list of proteins that make up our cells, we are still far from understanding how all of these molecular components come together to generate living systems. By combining recent advances in gene editing, fluorescence microscopy, proteomics and data science, Leonetti’s CZ Biohub team aims to understand how cells are internally organized in space and time. Their OpenCell project describes the localization and interactions of over 1,300 human proteins, providing a systems-level map of the human proteome. A direct objective is to unravel the cellular changes at play when diseases strike. In particular, and in collaboration with many colleagues at the Biohub, the Leonetti group seeks to comprehensively characterize how host human cells are remodeled during viral infection.

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