Physician-Scientist Research Symposium 2023

Deepak Srivastava, M.D.

Keynote Speaker

When

Friday, June 23, 2023 | 1-6 p.m.

Where

Mission Bay Conference Center
in the William J. Rutter Center
1675 Owens Street, San Francisco

REGISTRATION CLOSED

Creation of durable knowledge that can enhance human health demands testing at the bedside as well as in the laboratory. Physician-scientists are well positioned to bridge the ever-widening distance between practicing clinicians and fundamental scientific disciplines. Unfortunately, over the last 30 years, as resources and institutionally-supported time dedicated to research have become increasingly scarce, proportionately fewer physician-scientists have committed to a research-intensive career. To apply the power of fundamental scientific discovery to human health, the supply of early-career physician-scientists must be sustained and replenished.

The Physician-Scientist Research Symposium aims to bring together physician-scientists from UCSF and Stanford University, with the Chan Zuckerberg Biohub San Francisco as the convergence point, in order to build a research community of early-career physician-scientists and advocate for the continued engagement of physicians in scientific discovery.

ABOUT

The symposium celebrates the research accomplishments of CZ Biohub SF Physician-Scientist Fellows from Stanford and UCSF who have participated in a two- to three- year research training and career development program to develop their expertise and prepare them for careers as independent investigators.

In addition to lightning talks from Fellows, the Symposium features a research and career retrospective keynote from Gladstone Institutes President Deepak Srivastava and a panel discussion of faculty at UCSF and Stanford on the challenges facing early-career physician-scientists and recommendations for institutional and grassroots solutions to support and promote physicians engaged in scientific discovery.

The symposium will be followed by a poster and networking session. Early-career physician-scientists at UCSF and Stanford are invited to present a poster on their research.

KEYNOTE SPEAKER

Deepak Srivastava, M.D.

President and Senior Investigator
Gladstone Institutes

PANELISTS

Vinicio de Jesus Perez, M.D.

Co-Director of Translational Investigator Program Associate Professor of Medicine (Pulmonary and Critical Care Medicine) Stanford University School of Medicine

Jennifer Grandis, M.D.

Professor of Otolaryngology-Head and Neck Surgery UCSF School of Medicine

Arun Padmanabhan, M.D., Ph.D.

Co-Director, CZ Biohub SF Physician-Scientist Fellowship Program Assistant Professor of Medicine (Cardiology) UCSF School of Medicine

Mercedes Paredes, M.D., Ph.D.

Associate Director of Medical Scientist Training Program Associate Professor of Neurology UCSF School of Medicine

PJ Utz, M.D.

Director of Physician Scientist Training Program Professor of Medicine (Immunology and Rheumatology) Stanford University School of Medicine

PROGRAM

ALL TIMES IN PACIFIC TIME

Fri Friday

June 23

Registration

12:30 - 1:00 p.m.

Welcome Address and Introduction to Keynote Speaker

1:00 - 1:15 p.m.

David Cornfield, M.D

Co-Director, CZ Biohub SF Physician-Scientist Fellowship Program

Arun Padmanabhan, M.D., Ph.D.
Co-Director, CZ Biohub SF Physician-Scientist Fellowship Program and Assistant Professor of Medicine, UCSF School of Medicine

Keynote

1:15 - 2:00 p.m.

Deepak Srivastava, M.D.

President and Senior Investigator, Gladstone Institutes

CZ Biohub Physician-Scientist Fellow Talks

2:00 - 3:00 p.m.

William Temple, M.D.

“Taking the new CAR for a spin: CD72 nanoCARs for B cell malignancies”

Alan Baik, M.D.

“The problem with Fe-S clusters in hyperoxia: investigating the mechanisms of oxygen toxicity”

Anya Levinson, M.D.

“Preclinical studies of a novel pan-Raf inhibitor in pediatric AML”

Jacob Young, M.D.

“Reprogramming the immunosuppressive glioblastoma microenvironment using convection-delivered gene therapy”

Matthew McCarra, M.D.

“TERT expressing alveolar type II cells as unipotent progenitors of the distal lung”

Break

3:00 - 3:25 p.m.

Coffee break

CZ Biohub Physician-Scientist Fellow Talks

3:25 - 4:15 p.m.

John Gubatan, M.D.

“Single-cell transcriptomic analysis reveals tissue neutrophil heterogeneity and molecular signatures in ulcerative colitis associated with biologic therapy response”

Vanessa Kennedy, M.D.

“Multiomic single-cell sequencing reveals genetic and immunophenotypic clonal selection in patients with FLT3-mutated AML treated with gilteritinib/venetoclax”

Christopher Molina, M.D.

“Enhanced proliferation of profibrotic fibroblasts in pulmonary fibrosis”

Paul Sampognaro, M.D.

“Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by the lysosomal protease”

Panel Discussion

4:15 - 5:00 p.m.

Prescriptions to Revitalize the Physician-Scientist Workforce

Vinicio de Jesus Perez, M.D.

Co-Director of Translational Investigator Program and Associate Professor of Medicine (Pulmonary and Critical Care Medicine), Stanford University School of Medicine

Jennifer Grandis, M.D.

Professor of Otolaryngology-Head and Neck Surgery, UCSF School of Medicine

Arun Padmanabhan, M.D., Ph.D.

Co-Director, CZ Biohub SF Physician-Scientist Fellowship Program and Assistant Professor of Medicine (Cardiology), UCSF School of Medicine

Mercedes Paredes, M.D., Ph.D.

Associate Director of Medical Scientist Training Program and Associate Professor of Neurology, UCSF School of Medicine

PJ Utz, M.D.

Director of Physician Scientist Training Program and Professor of Medicine (Immunology and Rheumatology), Stanford University School of Medicine