Chan
Zuckerberg
Biohub
San Francisco

We bring together skilled and creative scientists and engineers to develop new technologies and tackle ambitious research projects, with the aim of understanding dynamic cell systems across scales in both healthy and diseased states.

We also join forces with the Bay Area’s leading academic institutions to support bold, visionary science that can’t be done elsewhere.

CZ Biohub San Francisco is part of the CZ Biohub Network, a group of nonprofit research institutes created and supported by the Chan Zuckerberg Initiative.

Cell division visualized by label-free imaging
Light-sheet microscopy of zebrafish development
Two researchers building the Remoscope, a malaria diagnostic tool
Building the Remoscope, a malaria diagnostic tool

Cells & Cell Systems

Cells are the fundamental unit of life. Our goal is to understand dynamic cell systems across scales, in both healthy and diseased states.

UMAP depicting human cell types in the Tabula Sapiens
UMAP depicting human cell types in the Tabula Sapiens
Two researchers building the Remoscope, a malaria diagnostic tool
Light-sheet microscopy of zebrafish development
Cell division visualized by QLIPP label-free imaging
Cell division visualized by QLIPP label-free imaging
UMAP depicting human cell types in the Tabula Sapiens
UMAP depicting human cell types in the Tabula Sapiens

Dynamic …

We invent and apply state-of-the-art imaging technologies in living cells and organisms, and develop the computational tools to mechanistically interpret intracellular and intercellular behaviors.

across scales …

Our Research Groups explore cell systems at various scales, from molecules (metabolites, proteins, transcripts), to cells, tissues, organs, and whole organisms, to define cell types, states, and disease phenotypes.

At the grandest scale — in human populations — we enable pathogen surveillance and rapid outbreak response. In collaboration with experts at our partner institutions, both domestically and in low- and middle-income countries, we work to understand infectious disease and advance public health.

in health and disease

We map dynamic changes in cell behavior in response to disease and infection to define underlying mechanisms and to identify potential targets for therapeutic intervention and diagnostic tools.

And our Technology Platforms disseminate the technologies we develop — and the knowledge gained — world-wide through open-access publication and data portals.

INVESTIGATOR PROGRAM

Building community to catalyze innovation

The Investigator Program at CZ Biohub SF is funding research by world-renowned scientists, engineers, and technologists from Stanford University, UC Berkeley, and UCSF.

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Investigators at CZ Biohub
Tools & Technology
Label-free imaging combined with AI-powered virtual staining offers a game-changing alternative to conventional staining for many cell types
Virtual staining for real cells

Developed by CZ Biohub San Francisco scientists, Cytoland promises to accelerate research in cell biology, disease diagnosis, and drug ...

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Biohub Investigators
Biohub Investigator Helen Willsey usng frogs as a model organism
Frogs, genes, and cellular antennae: Unlocking the biology of autism

Using frogs as a model organism, CZ Biohub SF Investigator Helen Willsey is revealing surprising connections between autism and hair-like structures on the ...

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Biohub Investigators
A vaccine against dementia?

CZ Biohub San Francisco Investigator analyzes health record data to find evidence that a shingles vaccine can lower the chances of developing ...

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Catalysts of Change Icon Badge
Arming Burkina Faso scientists with new skills to fight dengue and other infectious diseases

Collaborations between CZ Biohub San Francisco and the Global Fund empower Burkina Faso to develop pathogen genomics testing capacities ...

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Cell Science
illustration of organelles in a cell
Location, location: Researchers map proteins across human cells

Organelle Profiling, developed by CZ Biohub San Francisco scientists, is a new tool to understand cells at an unprecedented level of ...

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Cell Science
A simple model for an intricate, ever-evolving structure

Scientists use math and physics to address the mystery of just how the endoplasmic reticulum, an organelle essential to life at the cellular level, continually ...

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BioengineeringInfectious Disease
AI powers a better way to diagnose malaria

CZ Biohub San Francisco’s Remoscope shows promise in clinical ...

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Our Research

CZ Biohub San Francisco produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. Explore a selection of publications and preprints from across our institutes and grant partners.

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Shots of CZ Biohub SF doing research in three bubbles Shots of CZ Biohub SF doing research in three bubbles