Sleep is critical for health and chronic sleep deprivation increases risk for virtually all diseases. Despite this, we know very little about what sleep is and how it’s regulated. This symposium will explore our understanding of sleep physiology and basic biology related to sleep. It will also review the contributions genetics is making toward understanding sleep regulation and sleep disorders. Emerging technical tools are contributing to our ability to better understand sleep. And increasing knowledge about molecular and circuit level regulation of sleep will ultimately enable more rational approaches to improving sleep in patients with sleep disorders.

WEDNESDAY, JANUARY 15, 2020

8:55 a.m. – Welcome to Sleep Symposium

BASIC BIOLOGY

9:00 a.m. – Sleep and synaptic homeostasis

9:25 a.m. – A motor theory of sleep-wake control

  • Yang Dan, University of California, Berkeley & Howard Hughes Medical Institute

9:50 a.m. – Fluorescent polysomnography for single cell resolution whole-body comprehension of sleep

10:45 a.m. – The impact of sleep on oxidative stress

SLEEP AND CIRCADIAN RHYTHM GENETICS AND PHYSIOLOGY

11:10 a.m. – Is a broken clock right twice a day? Regulation of sleep and waking functions by the circadian timing system

11:35 a.m. – Genetics and biology of human circadian regulation

1:15 p.m. – Sleep and the human brain

1:40 p.m. – Understanding sleep efficiency

2:05 p.m. – Large-scale direct neurophysiology and modulation of sleep dynamics in humans

GENETICS/PATHOPHYSIOLOGY OF SLEEP DISORDERS

3:00 p.m. – Insomnia – blame is all on restless legs syndrome?

  • Juliane Winkelmann, Technical University Munich & Helmholtz Zentrum Munich, Institute of Neurogenomics

3:25 p.m. – A mechanism for sleep instability during aging

3:50 p.m. – Genetics of sleep disorders: from gene discovery towards biology and clinical translation

4:15 p.m. – Chicken or egg?: sleep, clocks, and neurodegeneration

4:40 p.m. – Poster Session/Reception

THURSDAY, JANUARY 16, 2020

THERAPIES FOR SLEEP DISORDERS

9:00 a.m. – Mechanism matters: the effects of insomnia drugs that are wake promoting neurotransmitter receptor antagonists vs. GABA-A allosteric modulators

9:25 a.m. – Novel tailored therapies for sleep apnea treatment and management: A respiratory phenotyping precision medicine approach

9:50 a.m. – Lightning Talks

10:45 a.m. – Lightning Talks

SLEEP ENGINEERING/TECHNOLOGY

11:15 a.m. – Future trends in sleep research and medicine

11:40 a.m. – Proteomic biomarkers of circadian rhythm and sleep debt

12:05 p.m. – Sleep tech: crossing the intimacy threshold

12:50 p.m. – Panel Discussion

Moderator – Katja Brose, Chan Zuckerberg Initiative

  • Jonathan Berent, Google X
  • Yang Dan, University of California, Berkeley & Howard Hughes Medical Institute
  • Emmanuel Mignot, Stanford University
  • Louis Ptáček, University of California, San Francisco
  • Richa Saxena, Harvard University