Our group explores virus–host interactions in cells infected with medically relevant viruses. Using comparative virology, we aim to identify and validate conserved nodes within the proteostasis network that can be targeted pharmacologically to develop broad-spectrum antivirals.
Carolina earned her Ph.D. degree at New York University School of Medicine, where she studied virus–host interactions in herpesviruses and poxviruses in the lab of Ian Mohr. As a postdoctoral fellow in the lab of Don Ganem at UC San Francisco and the Novartis Institutes for BioMedical Research, she studied the genome-wide transcriptional and translational regulation of the Kaposi’s sarcoma–associated herpesvirus (KSHV/HHV8). As a faculty member at UC Santa Barbara, she investigated the mechanisms by which herpesviruses and flaviviruses take control of the cell’s protein-synthesis and folding machineries. Using comparative virology and mechanistic analyses, Carolina’s team at CZ Biohub aims to uncover host-encoded viral vulnerabilities that can be exploited for developing next-generation broad-spectrum antivirals.