Diseases are caused by disruptions in the inner workings of cells or in the communication between cells. That’s why we support rigorous, quantitative research in molecular, cell, and developmental biology, and in infectious disease. Our scientists are showing how healthy cells are built and how they work and, more importantly, what takes place when disease strikes.
Bringing together cell biologists, data scientists, and engineers, the team led by Manuel Leonetti is building reference maps of how the human cell is internally organized. Their flagship project, OpenCell, characterizes the spatial locations and molecular interactions of the proteins that make up the cell.
A pluridisciplinary team of computer scientists, optical engineers, and biologists, Loïc Royer and his team are building Zebrahub, a time-resolved, multidimensional atlas of vertebrate development using zebrafish as a model organism.
Led by Greg Huber, a group of mathematicians and computational and theoretical physicists is working in close collaboration with experimental biologists, using tools from applied mathematics and theoretical physics to understand problems in cell biology and beyond.
Using a combination of zebrafish transgenesis, cutting-edge imaging tools, and mathematical modeling, Adrian Jacobo‘s group aims to understand how tissue architecture emerges from the spatial and temporal dynamics of cell–cell signaling.
The Rapid Response Team, led by Cristina Tato, is collaborating with health agencies in the U.S. and in low- and middle-income countries to build capacity in sequencing, metagenomics, and molecular epidemiology.
Ranen Aviner’s group uses molecular biology, transcriptomics, and proteomics to investigate how ribosomal networks change during viral infection or neurodegenerative disease, with the goal of designing rational therapeutic interventions.
Combining synthetic biology and genetic, biochemical, and computational approaches, Amy Kistler’s group aims to dissect and compare the minimal components, host-factor requirements, and function of diverse viral replication and transcription complexes.
The group led by Carolina Arias explores virus–host interactions in cells infected with medically relevant viruses. Using comparative virology, the team aims to identify and validate conserved nodes within the proteostasis network that can be targeted pharmacologically to develop broad-spectrum antivirals.