Director, Genomics Platform
In 2007 Norma came to work with Rick Myers who was the Chairman of Genetics at Stanford on the ENCODE project. After Rick moved his lab to Alabama, Norma started working for Steve Quake who is now co-president of CZ Biohub. CZ Biohub is an opportunity to work with a lot of interesting, smart people and do exciting work. In academia, you can spend a lot of time worrying about one gene and how it’s behaving. Norma wanted to do more diagnostics and translational research. One of Norma's jobs is to make the sequencing technology accessible to the academic community in the Bay Area. Norma looks forward to interacting with all sorts of different people. The team is on the hunt for researchers with unique collections of clinical samples. Maybe they have thought about sequencing them but never had the chance because it seems challenging and expensive. Norma likes delivering sequence data to researchers, giving them an opportunity to look at their cells in a more unbiased and quantitative way. Norma continues to work at Stanford as well. She is responsible for single cell sequencing at both places. This includes working on the Cell Atlas project.
Senior Research Associate, Genomics Platform
Michael Borja is a Senior Research Associate at CZ Biohub for the Genomics Platform. He was an integral part of the team that worked on the MACA (Mouse Aging Cell Atlas) project. Now, Michael designs and carries out single cell experiments as part of various internal and external collaborations using plate-based and droplet workflows. In addition, he is also involved with post sequencing data analysis such as performing genome alignment, matrix count generations and some differential gene expression analysis. Lastly, Michael handles the organization and logistics of the Genomics Platform . For the past two years, he organizes Biohub's Internal Seminar series, creating a forum for researcher and employees to share and discuss groundbreaking research products. Prior to Biohub, he's worked at Biotech companies such as Zymergen and Illumina.
Scientist II, Genomics Platform
Angela Detweiler holds a B.S. in Ecology and Environmental Biology, and a M.S. in Biology. Prior to joining CZ Biohub she spent some years at NASA ARC studying the structural and functional diversity of hypersaline microbial mats. She also collaborated on a spaceflight experiment and payload integration to assess the effects of microgravity and radiation on B. subtilis. Since joining the platform in 2019, she has been involved in Biohub's CLIAhub, CA Covid Tracker and Cell Atlas projects. She also provides sequencing training to local and global health staff, aimed at facilitating pathogen detection and discovery. Angela oversees daily sequencing operations on a variety of platforms and enjoys beta-testing novel sequencing technologies and protocols.
Research Associate I, Genomics Platform
After graduating from the University of California, Santa Cruz, Honey joined an Immune-Genomic methods lab led by Professor Christophers Vollmers, where she worked on generating whole transcriptome annotation and analysis of organisms using an in-house method called Rolling Circle Amplification to Concatemeric Consensus (R2C2). Later on, she took part in an ongoing project looking at the effect of long term smoking on the T-cells and B-Cells of the Human Immune Repertoire. In this project, she worked on generating high quality cDNA libraries for Illumina sequencing. As part of the Genomics Platform at CZ Biohub, she works on NGS technology to provide high quality data for both internal and external investigators. Honey's role on the Genomics Platform extends to providing consultation on best practices of sequencing experimental design, troubleshooting the sequencing process, and maintaining good communication with collaborators to ensure projects receive optimal sequencing data.
Research Associate II, Genomics Platform
Sheryl moved from Mumbai to the US to pursue her Masters in Biotechnology from the University of California, Irvine. At UCI, she worked in Dr. Ken Cho's lab, where she studied the effects of maternal transcription factors on gene regulatory networks of Xenopus Tropicalis embryos. After graduation, she moved to the East Coast where she worked with investigators at the National Institutes of Health to design, plan and execute sequencing projects for Cancer research. At CZ Biohub, she works with different internal and external collaborators to generate high quality sequencing data for cell type identification, gene therapy, and diagnostics using NGS. She is also part of the public health outreach program which is funded by the Gates foundation where she provides NGS expertise to global health researchers who use genomics for surveillance of infectious diseases.
Research Associate II
Amanda Seng received her B.A. in Molecular and Cell Biology from the University of California, Berkeley, and M.Sc. in Molecular Medicine from Charité Medical University of Berlin, Germany. Her thesis research was on cell fate plasticity during early development of the zebrafish embryo using RNA-labeling techniques at the Max Delbruck Center for Molecular Medicine in Berlin. She also has experience working on direct reprogramming in C. elegans using CRISPR techniques, and molecular phylogenetic on Peperomia and Orobanche. Previously she worked as application scientist on next-generation sequencing in Malaysia, her home country. At the CZ Biohub Stanford BioCAT she works on single-cell transcriptomics and genomic sequencing for internal and external researchers and Human Microbiome projects.
Research Associate I, Genomics Platform
Before joining the Biohub as a research associate in the Genomics Platform Vanessa dabbled in space biology, single molecule localization microscopy, engineering 3D stem cell microenvironments and microfluidics fabrication. Currently, Vanessa works on various applications of spatial transcriptome profiling technologies, including multiplexed error-robust fluorescence in situ hybridization (MERFISH) and 10x Visium. In addition, she carries out several internal and external collaborations to prepare multi omic single cell ATAC-seq libraries for Illumina sequencing. She also enjoys tackling the challenge of translating complex research concepts into more easily digestible (and aesthetically pleasing) illustrations and schematics.
Jia Rose Yan
Research Associate II, Genomics Platform
Rose Yan received her B.S. in Microbiology and M.S. in Food Microbiology from University of California, Davis. She carried out her thesis research in the Robert Mondavi Institute, where she developed a methodology to study the survival of foodborne pathogens (Salmonella, Listeria monocytogenes, and E. coli) on coffee beans and in cold brew coffee. In her previous research, she also studied the effects of water saving AWD60 irrigation on the microbial communities associated with rice roots using 16S rRNA sequencing. At CZ Biohub, she works with internal and external collaborators to prepare DNA libraries and sequence samples on Illumina and nanopore platforms. She is also partially involved with the microbiome initiative at Stanford University and is interested in understanding community effects of the human gut microbiome.
Feiqiao Brian Yu
Senior Scientist, Genomics Platform
Brian Yu received his Ph.D. in Electrical Engineering and carried out his thesis research in Stephen Quake’s lab in Bioengineering at Stanford University, where he developed high-throughput microfluidic and sequencing technologies to study microbes. He also created Mini-Metagenomics, a microfluidic method to sequence and constructing genomes of novel bacterial organisms from mixed communities. At CZ Biohub, Brian collaborates with faculties from Stanford, UCSF, and Berkeley who make up the Biohub Microbiome Intercampus Initiative. His research focuses at the intersection of multi-omics and the human gut microbiome, inventing high-throughput experimental and data analysis platforms with the aim of understanding strain-strain and strain-nutrient interactions. As a member of the Genomics Platform, Brian actively incorporates new sequencing technologies that benefit Biohub’s central research aims. In addition, he builds, maintains, and updates user-facing computational infrastructure, enabling user interactions with genomic platform capabilities.