Shalin Mehta developed signal processing algorithms for radars, before earning a Ph.D. in optics at the National University of Singapore from Colin Sheppard’s lab. His Ph.D. research led to elegant mathematical models and new label-free imaging technologies. He then worked at the intersection of technology development and quantitative biology at the Marine Biological Laboratory in Woods Hole as a Human Frontier Science Program (HFSP) Fellow. His postdoctoral research led to novel computational imaging methods to measure the molecular order of the cytoskeleton beyond the resolution limit. At CZ Biohub, Mehta leads the Computational Microscopy platform; he and his team integrate optics, inverse algorithms, and machine learning to build computational microscopy platforms that measure the biological architecture and activity with increasing accuracy, precision, and throughput. These technologies are developed and deployed to discover biological mechanisms and therapeutic opportunities in close collaboration with CZ Biohub’s projects, platforms, and partners.