Manuel Leonetti, Ph.D.

Sr. Group Leader & Director of Systems Biology

Manuel Leonetti received his Ph.D. from The Rockefeller University. As a student in Rod MacKinnon’s lab, he used X-ray crystallography and electrophysiology to study the relationship between atomic structure and functional regulation of ion channel proteins. As a postdoctoral fellow with Jonathan Weissman at the University of California, San Francisco, he developed high-throughput CRISPR methods to precisely and efficiently edit the human genome. At CZ Biohub SF, Leonetti and his team are mapping the internal architecture of a single human cell. Their flagship project – OpenCell – is a proteome-scale library of fluorescently engineered cell lines to define the localization and interactions of human proteins. Their current dataset includes over 1,300 proteins and can be explored through an interactive interface at