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Ethan Weiss, M.D.

CZ Biohub Physician-Scientist Program Co-Director

Weiss is Associate Professor of Medicine at the University of California, San Francisco, and a Principal Investigator in UCSF’s Cardiovascular Research Institute (CVRI).

Weiss received his M.D. from Johns Hopkins University School of Medicine, where he also completed his internship and residency. He came to UCSF in 1998 to complete his cardiology fellowship and research training.

Weiss’ clinical interests include prevention, lipids, and the emerging intersection of endocrinology and cardiology, with a specific focus on pre-diabetes and Type 2 diabetes as risk factors for coronary disease. In addition, he has interests in the genetics of coronary disease, cardiovascular risk assessment, nutrition and lifestyle, and heart disease in the young. He works with his patients to use rational and evidence-based approaches — including lifestyle modifications and drug therapy when necessary — to improve cardiovascular risk. His research interests are focused on understanding the mechanisms of metabolic disorders such as obesity, fatty liver disease, and diabetes, including the role of growth hormone signaling and lipid metabolism. He also has an active program in clinical nutrition.

He has served as Principal Investigator on grants funded by the National Heart, Lung, and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases. He serves on the scientific advisory boards of multiple companies focused on using technology to favorably impact human health. He is a recent co-founder of Keyto Inc., a San Francisco-based company aiming to facilitate the use of the ketogenic diet for weight loss.